49ers Schedule 2025 2025. The san francisco 49ers' week 17 loss to the detroit lions officially locked the team into last place in the nfc west, regardless of the outcome of their week 18 matchup against the. The san francisco 49ers’ regular season began on september 9, 2024, and will end on january 5, 2025.
View the 2025 san francisco 49ers schedule at fbschedules.com. Ten teams have at least 11 losses this season and seven of those teams are on the 49ers’ 2025 schedule, which includes just two teams that currently have a winning record.